Pharmacogenetics (PGX) Testing

Your genes determine your characteristics, from eye color to blood type. Some genes determine how your body will react to or processes medications. Spark Labs provides pharmacogenetic testing to help your health care team determine which medications will be best for you in choosing the right treatment plan for your needs.

What is Pharamacognenetic Testing?

Pharmacogenetics is the study of how people respond differently to drug therapy based upon their genetic makeup or genes. Your diet, overall health, and your environment also have a significant influence on medication response, but there is no stronger indication of how you will process medication than your genetics.

Pharmacogenetic testing looks for changes in your genes or variants that can determine whether a certain medication can effectively treat you or whether you will likely have side effects to a medication.

Benefits of Pharmacogenetic Testing

Individuals may respond differently to the same medication. The same medication may achieve the desired response in some people, have no effect on others, and cause severe side effects for others. Pharmacogenetic testing ensures your medical team knows ahead of time which effects, positive or negative, could be caused by a medication: the results are that you are treated correctly and with the correct medication for you.

Benefits of pharmacogenetic testing includes the following benefits:

Prevents reverse drug reactions
Ensures better and more effective healthcare
Provides medication specific to the genetic makeup of patients
Lowers patient medical costs as their treatment is customized for them
Helps determine the proper dosage for each patient
Increases patient safety

What Happens During a Pharmacogenetic Test?

A pharmacogenetic test is typically done as a blood or saliva test. Once a small amount of these substances are collected, the DNA is examined for genetic variants that are associated with a variable response to specific medications.

These variants occur in genes that code for enzymes that metabolize drugs and proteins involved in immune response. Pharmacogenetic tests can determine certain qualities of a variant, which impacts an individual's response or reaction to a drug. Because a person’s genetic makeup doesn’t change, pharmacogenetic testing for a specific gene is only performed once.

Depending on the medication being tested, a single gene may be ordered or multiple genes may be ordered.

Pharmacogenetic testing at Spark Labs

At Spark Labs, we provide a comprehensive portfolio of genetic panels to choose from.

Cardio

Actionable Cardiovascular (32 genes)

ACTA2, ACTC1, APOB, CACNA1S, COL3A1, DSC2, DSG2, DSP, FBN1, GLA, KCNH2, KCNQ1, LDLR, LMNA, MYBPC3, MYH11, MYH7, MYL2, MYL3, PCSK9, PKP2, PRKAG2, RYR1, SCN5A, SMAD3, TGFBR1, TGFBR2, TMEM43, TNNI3, TNNT2, TPM1

Hereditary Cardio Screen Focus  (44 genes)

ACTA2, ACTC1, APOB, BAG3, CACNA1S, COL3A1, DES, DSC2, DSG2, DSP, F9, FBN1, FLNC, GLA, JUP, KCNH2, KCNQ1, LDLR, LMNA, MYBPC3, MYH11, MYH7, MYL2, MYL3, MYLK, PCSK9, PKP2, PRKAG2, PRKG1, RBM20, RYR1, RYR2, SCN5A, SMAD3, TGFB2, TGFBR1, TGFBR2, TMEM43, TNNC1, TNNI3, TNNT2, TPM1, TTN, TTR

Comprehensive Cardiomyopathy (129 genes)

A2ML1, ABCC9, ACADVL, ACTC1, ACTN2, ADA2, AGL, AKAP9, ALMS1, ANK2, ANKRD1, BAG3, BRAF, CACNA1C, CACNB2, CALR3, CASQ2, CAV3, CAVIN4, CBL, CHRM2, CPT2, CRYAB, CSRP3, CTF1, CTNNA3, DES, DMD, DNAJC19, DOLK, DSC2, DSG2, DSP, DTNA, ELAC2, EMD, EYA4, FHL1, FHL2, FKRP, FKTN, FLNC, FXN, GAA, GATA4, GATA6, GATAD1, GLA, GPD1L, HCN4, HRAS, ILK, JPH2, MTO1, MYBPC3, MYH6, MYH7, MYL2, MYL3, MYLK2, MYOM1, MYOZ2, MYPN, NDUFB11, NEBL, NEXN, NF1, NKX2-5, NPPA, NRAS, PDLIM3, PKP2, PLN, PRDM16, PRKAG2, PTPN11, RAF1, RANGRF, RASA1, RBM20, RIT1, RRAS, RYR2, SCN1B, SCN3B, SCN4B, TNNC1, TNNI3, TNNT2, TPM1, TRDN, TTN, TTR, TXNRD2, VCL, YWHAE

Familial Hypercholesterolemia (4 genes)

APOB, LDLR, LDLRAP1, PCSK9

Hereditary Cardio Screen (117 genes)

ABCC9, ACTA2, ACTC1, ACTN2, ACVRL1, AGL, AKAP9, ALMS1, ANK2, APOB, BAG3, BMPR2, CACNA1C, CACNA1S, CACNB2, CALM1, CALM2, CALM3, CASQ2, CAV1, CAV3, COL3A1, CRYAB, CSRP3, DES, DMD, DOLK, DSC2, DSG2, DSP, EMD, ENG, EYA4, F9, FBN1, FHL1, FKRP, FKTN, FLNC, GAA, GATAD1, GDF2, GLA, GPD1L, HCN4, JPH2, JUP, KCNA5, KCND3, KCNE1, KCNE2, KCNE3, KCNH2, KCNJ2, KCNJ5, KCNQ1, LAMA4, LAMP2, LDB3, LDLR, LDLRAP1, LMNA, MYBPC3, MYH11, MYH6, MYH7, MYL2, MYL3, MYLK, MYOZ2, MYPN, NEXN, NKX2-5, PCSK9, PKP2, PLN, PRKAG2, PRKG1, PROC, PROS1, PTPN11, RAF1, PBM20, RIT1, RYR1, RYR2, SCN10, SCN1B, SCN2B, SCN3B, SCN4B, SCN5A, SERPINC1, SCGCD, SLC22A5, SMAD3, SMAD4, SNTA1, SOS1, TAZ, TBX20, TBX5, TCAP, TGFB2, TGFB3, TGFBR1, TGFBR2, TMEM43, TNNC1, TNNO3, TNNT2, TPM1, TRDN, TRPM4, TTN, TTR, VCL

PGX

PGx Comprehensive (44 genes)

ABCB1, ACE, ANKK1, APOE, ATM, BCHE, CES1, COMT, CYP2B6, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP3A4, CYP3A5, CYP4F2, DPYD, DRD2, ERCC1, F2, F5, G6PD, GGCX, GRIK4, GSTP1, HLA-B, HTR1A, HTR2A, HTR2C, IFNL4, ITPA, KIF6, MTHFR, NAT2, NQO1, NUDT15, OPRM1, RYR1, SLCO1B1, TPMT, UGT1A1, UGT1A4, VKORC1, XRCC1

PGx Orthopedic Panel (7 genes)

CYP2D6, CYP3A4, CYP3A5, F2, F5, MTHFR, VKORC1

PGx Focus (18 genes)

BCHE, CYP2B6, CYP2C19, CYP2C9, CPY2D6, CPY3A5, CPY4F2, DPYD, G6PD, HLA-B, IFNL4, NAT2, NUDT15, RYR1, SLCO1B1, TPMT, UGTA1, VKORC1

PGx Pain Management Panel (5 genes)

COMT, CYP2C19, CYP2D6, CYP3A4, CYP3A5

PGx Mental Health Panel (4 genes)

CYP2C19, CYP2D6, CYP3A4, CYP3A5

PGx Urology Panel (4 genes)

CYPC219, CYP2C9, CYP2D6, CYP3A4

Cancer CGx

BRCA1 and BRCA2 Focus (2 genes)

BRCA1, BRCA2

Comprehensive Cancer Nerves Brain (27 genes)

ALK, APC, ATM, DICER1, EPCAM, HRAS, LZTR1, MEN1, MLH1, MSH2, MSH6, NF1, NF2, PHOX2B, PMS2, POT1, PRKAR1A, PTCH1, PTEN, SMARCA4, SMARCB1, SMARCE1, SUFU, TP53, TSC1, TSC2, VHL

Comprehensive Cancer Prostate (12 genes)

ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, NBN, PALB2, PTEN, STK11, TP53

Custom CGX Lynch Syndrome (5 genes)

EPCAM, MLH1, MSH2, MSH6, PMS2

Custom CGX Uterine Cancer (8 genes)

EPCAM, MLH1, MSH2, MSH6, PMS2, PTEN, STK11, TP53

Custom CGX Comprehensive Cancer (44 genes)

APC, ATM, BAP1, BARD1, BLM, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN2A, CHEK2, EPCAM, FANCA, FANCB, FANCC,
FANCD2, FANCE, FH, MEN1, MET, MITF, MLH1, MRE11, MSH2, MSH6, MUTYH, NBN, NF1, PALB2, PMS2, POLD1, POLE, PTCH1,
PTEN, RAD50, RAD51C, RAD51D, RET, SMAD4, STK11, TP53, VHL

CGx Comprehensive Complete Cancer Panel (82 genes)

AIP, ALK, APC, ATM, AXIN2, BAP1, BARD1, BLM, BMPR1A, BRCA1, BRCA2, BRIP1, CASR, CDC73, CDH1, CDK4, CDKN1B, CDKN1C, CDKN2A, CEBPA, CHEK2, CTNNA1, DICER1, DIS3L2, EPCAM, FH, FLCN, GATA2, GPC3, CREM1, HOXB13, HRAS, KIT, MAX, MEN1, MET, MITF, MLH1, MSH2, MSH6, MUTYH, NBN, NF1, NF2, NTHL1, PALB2, PDGFRA, PHOX2B, PMS2, POLD1, POLE, POT1, PRKAR1A, PTCH1, PTEN, RAD50, RAD51C, RAD51D, RB1, RECQL4, RET, RUNX1, SDHA, SDHAF2, SDHB, SDHC, SDHD, SMAD4, SMARCA4, SMARCB1, SMARCE1, STK11, SUFU, TERC, TERT, TMEM127, TP53, TSC1, TSC2, VHL, WRN, WT1

Custom CGX Colorectal Cancer (14 Genes)

APC, BMPR1A, EPCAM, MLH1, MSH2, MSH6, MUTYH, PMS2, POLD1, POLE, PTEN, SMAD4, STK11, TP53

Custom CGX Ovarian Cancer (17 genes)

BARD1, BRCA1, BRCA2, BRIP1, CDH1, EPCAM, MLH1, MSH2, MSH6, NBN, PALB2, PMS2, PTEN, RAD51C, RAD51D, STK11, TP53

Custom CGX Breast Cancer (12 genes)

ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, NBN, PALB2, PTEN, STK11, TP53

Comprehensive Breast and Ovarian Cancer Panel (25 genes)

ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, EPCAM, MLH1, MRE11, MSH2, MSH6, MUTYH, MBM, MF1, PALB2, PMS2, PTEN, RAD50, RAD51C, RAD51D, SMARCA4, STK11, TP53, XRCC2

Comprehensive Cancer Ovarian (19 genes)

BARD1, BRCA1, BRCA2, BRIP1, CDH1, EPCAM, MLH1, MRE11, MSH2, MSH6, MUTYH, NBN, PAB2, PMS2, RAD51C, RAD51D, SMARCA4, STK11, TP53

Custom CGX Comprehensive Cancer (44 genes)

APC, ATM, BAP1, BARD1, BLM, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN2A, CHEK2, EPCAM, FANCA, FANCB, FANCC, FANCD2, FANCE, FH, MEN1, MET, MITF, MLH1, MRE11, MSH2, MSH6, MUTYH, NBN, NF1, PALB2, PMS2, POLD1, POLE, PTCH1, PTEN, RAD50, RAD51C, RAD51D, RET, SMAD4, STK11, TP53, VHL

Custom CGX Pancreatic Cancer (14 genes)

APC, ATM, BMPR1A, BRCA1, BRCA2, CDKN2A, CHEK2, EPCAM, MLH1, MSH2, PALB2, SMAD4, STK11, TP53

Myeloid Cancer (17 genes)

CEBPA, EZH2, FANCA, FANCB, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCL, FANCM, GATA2, NSD1, RUNX1, SBDS, TP53

Other Panels

Comprehensive Respiratory Disorder (81 genes)

ABCA3, ACVRL1, AP3B1, ARMC4, ASCL1, BDNF, BLOC1S3, BLOC1S6, BMPR2, CAV1, CCDC103, CCDC114, CCDC151, CCDC39, CCDC40, CCDC65, CCNO, CFAP298, CFTR, DNAAF1, DNAAF2, DNAAF3, DNAAF4, DNAAF5, DNAH11, DNAH5, DNAI1, DNAI2, DNAJB13, DNAL1, DRC1, DTNBP1, EDN3, EFEMP2, ELN, ENG, FBLN5, FLCN, FOXF1, GAS8, GDNF, HPS1, HPS3, HPS4, HPS5, HPS6, HYDIN, INVS, KCNA5, KCNK3, LRRC6, LTBP4, MCIDAS, MUC5B, NKX2-1, NME8, OFD1, PHOX2B, PIH1D3, RET, RPGR, RSPH1, RSPH3, RSPH4A, RSPH9, RYR1, SCNN1A, SCNN1B, SCNN1G, SERPINA1, SFTPA1, SFTPA2, SFTPB, SFTPC, SMAD9, SPAG1, TERC, TERT, TSC1, TSC2, ZMYND10

Diabetes-Obesity (56 genes)

ABCC8, ADRB2, ADRB3, AGRP, ALMS1, ARL6, BBS1, BBS10, BBS12, BBS2, BBS4, BBS5, BBS7, BBS9, BDNF, CARTPT, CEL, CEPT290, EIF2AK3, ENPP1, FOXP3, GCK, GHRL, GLIS3, GNAS, HNF1A, HNF1B, HNF4A, INS, KCNJ11, LEP, LEPR, MAGEL2, MC4R, MKKS, MKS1, NEUROD1, NEUROG3, NTRK2, PCSK1, PDX1, POMC, PPARG, PPARGC1B, PTF1A, PYY, RFX6, SDC3, SDCCAG8, SIM1, TRIM32, TTC8, UCP1, UCP3, WDPCP, WFS1

Custom Alzheimer and Dementia (16 genes)

APOE, APP, C9orf72, CSF1R, DNMT1, EIF4G1, GBA, GRN, MAPT, PRNP, PSEN1, PSEN2, SNCA, SNCB, TREM2, TYROBP

Lung Disorders Comprehensive (53 genes)

ABCA3, ACVRL1, AP3B1, ASCL1, BDNF, BLOC1S3, BLOC1S6, BMPR2, CCDC39, CCDC40, CFTR, DNAAF1, DNAAF2, DNAH11, DNAH5, DNAI1, DNAI2, DNAL1, DTNBP1, EDN3, EFEMP2, ELN, ENG, FLBN5, FBN1, FLCN, GDNF, HPS1, HPS3, HPS4, HPS5, HPS6, LTBP4, MUC5B, NF1, NME8, PHOX2B, RET, RSPH4A, RSPH9, SCNN1A, SCNN1B, SCNN1G, SERPINA1, SFTPA1, SFTPA2, SFTPB, SFTPC, SMAD9, TERC, TERT, TSC1, TSC2

Custom Parkinson-Alzheimer-Dementia (35 genes)

APOE, APP, ATP13A2, ATP1A3, C9orf72, CSF1R, DCTN1, DNMT1, EIF4G1, FBXO7, GBA, GCH1, GRN, HTRA2, LRRK2, MAPT, NOTCH3, PARK7, PINK1, PLA2G6, POLG, PRKN, PRKRA, PRNP, PSEN1, PSEN2, SLC6A3, SNCA, SNCB, TAF1, TH, TREM2, TYROBP, UCHL1, VPS35

Primary Immunodeficiency Focus (108 genes)

ADA, AICDA, ATM, B2M, BCL10, BLM, BLNK, BTK, CARD11, CCBE1, CD19, CD27, CD3D, CD3E, CD3G, CD40LG, CD79A, CD79B, CD81, CD8A, CHD7, CIITA, CR2, CTC1, CTLA4, DCLRE1C, DKC1, DNMT3B, DOCK8, EXTL3, FAT4, FOXN1, GATA2, ICOS, IGLL1, IKBKB, IL21R, IL2RG, IL7R, ITK, JAK3, KDM6A, KMT2D, LCK, LIG1, LRBA, LRRC8A, MAGT1, MALT1, MAP3K14, MCM4, MOGS, MS4A1, NBN, NFKB2, NFKBIA, NHEJ1, NHP2, NOP10, ORAI1, PIK3CD, PIK3RI, PLCG2, PNP, POLE, POLE2, RAG1, RAG2, RFX5, RFXANK, RFXAP, RHOH, RMRP, RNF168, RTEL1, SEMA3E, SH2D1A, SLC46A1, SMARCAL1, SP110, SPINK5, STAT3, STAT5B, STIM1, STK4, STXBP2, TBX1, TCF3, TCN2, TERC, TERT, TFRC, TINF2, TNFRSF13B, TNFRSF,13C, TRNT1, TTC37, TTC7A, TYK2, UNG, USB1, WAS, WIPF1, WRAP53, XIAP, ZAP70, ZBTB24

Why Choose Spark Labs?

Our single focus at Spark Labs is to provide expert testing services, including pharmacogenetic testing, to improve the field of health care and achieve better wellness results.

Spark Labs is known as one of the most credible and trusted testing resources in the industry because we provide reliable results time and time again. We are proud to partner with the medical community by providing pharmacogenetic testing, helping doctors care for their patients with the correct medications and proper amounts to achieve the best outcomes.